Potassium Carbonate → HCID 59300734, compound

Participants

Reaction Steps

Analogously to general procedure (I) N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide (2 g) is alkylated in a high pressure reaction vessel using 1-iodo-4,4,4-trifluoro-butane (3.62 g; 15.2 mmol) and K2CO3 (2.1 g; 15.2 mmol) at 60° C. for 3 days. After aqueous work-up and purification by RP chromatography the pure material (1.92 g) is de-acetylated in MeOH (200 ml) using DBU (1.6 ml) at reflux. After aqueous work-up 5-amino-3,3-dimethyl-6-nitro-1-(4,4,4-trifluoro-butyl)-1,3-dihydro-indol-2-one (1.65 g) is obtained and used without further purification.

Provenance & Evidence