Potassium Carbonate → HCID 59300748, compound

Participants

Reaction Steps

Analogously to general procedure (I) N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide (2 g) is alkylated in a high pressure reaction vessel using 1-iodo-3,3,3-trifluoro-propane (1.8 ml; 15.2 mmol) and K2CO3 (2.1 g; 15.2 mmol) at 60° C. for 14 days After aqueous work-up and purification by RP chromatography the pure material (0.38 g; 1.07 mmol) is de-acetylated in MeOH (80 ml) using DBU (0.3 ml) at reflux. After aqueous work-up 5-amino-3,3-dimethyl-6-nitro-1-(3,3,3-trifluoro-propyl)-1,3-dihydro-indol-2-one (0.34 g) is obtained and used without further purification.

Provenance & Evidence