Potassium Carbonate → HCID 59300940, compound

Participants

Reaction Steps

Analogously to general procedure (I) N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide (5 g) is alkylated in a high pressure reaction vessel using 2-iodo-1,1,1-trifluoro-ethane (5.7 ml; 38 mmol) and K2CO3 (5.25 g; 38 mmol) at 50° C. for 14 days. After aqueous work-up and purification by RP chromatography the pure material (4 g) is de-acetylated in MeOH (150 ml) using DBU (3.6 ml) at reflux. After aqueous work-up 5-amino-3,3-dimethyl-6-nitro-1-(2,2,2-trifluoro-ethyl)-1,3-dihydro-indol-2-one (3,34 g) is obtained and used without further purification.

Provenance & Evidence