Potassium Carbonate → HCID 59300929, compound

Participants

Reaction Steps

Analogously to general procedure (I) N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide (0.24 g) is alkylated using 4-bromobutyronitrile (0.1 ml; 1 mmol) and K2CO3 (0.28 g; 2 mmol) at 50° C. for 3 days. After aqueous work-up the crude material (0.4 g) is de-acetylated in MeOH (10 ml) using DBU (0.1 ml) at RT in 3 h. After aqueous work-up 4-(5-amino-3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-indol-1-yl)-butyronitrile (0.33 g) is obtained and used without further purification.

Provenance & Evidence