Potassium Carbonate → HCID 59300754, compound

Participants

Reaction Steps

Analogously to general procedure (I) N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide (0.57 g) is alkylated using 4-bromomethyl-2-fluoro-1-methoxy-benzene (0.5 g; 2.28 mmol) and K2CO3 (0.9 g; 6.52 mmol) at RT for 18 h. After aqueous work-up the crude material is de-acetylated in hydrochloric acid (20 ml; 6 N) at reflux. After aqueous work-up 5-amino-1-(3-fluoro-4-methoxy-benzyl)-3,3-dimethyl-6-nitro-1,3-dihydro-indol-2-one (0.68 g) is obtained and used without further purification.

Provenance & Evidence