Hexamethylenetetramine → 3,5-Difluoro-4-hydroxybenzaldehyde

Participants

Reaction Conditions

Reaction Steps

To a solution of 2,6-difluoro phenol (1 g; 7.69 mmol) in CF3COOH (10 ml) is added hexamethylene tetramine (1.08 g; 7.69 mmol) and the mixture is heated in a microwave apparatus at 130° C. for 15 min. After evaporation to dryness the residue is taken-up in CH2Cl2 and saturated K2CO3 solution. After acidification with hydrochloric acid the aqueous layer is extracted with CH2Cl2 (3×100 ml). The combined organic layer is washed with brine, dried over MgSO4 and evaporated to dryness to give 3,5-difluoro-4-hydroxy-benzaldehyde as a colourless solid (0.82 g).

Provenance & Evidence