Potassium Carbonate → HCID 59300819, compound

Participants

Reaction Steps

Analogously to general procedure (I) N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide (0.17 g) is alkylated using 5-chloromethyl-1,3-difluoro-2-isopropoxy-benzene (0.15 g; 0.68 mmol) and K2CO3 (0.3 g; 2.16 mmol) at RT for 18 h. After aqueous work-up the crude material (0.27 g) is de-acetylated in hydrochloric acid (30 ml; 6 N) at reflux. After aqueous work-up 5-amino-1-(3,5-difluoro-4-isopropoxy-benzyl)-3,3-dimethyl-6-nitro-1,3-dihydro-indol-2-one (0.20 g) is obtained and used without further purification.

Provenance & Evidence