HCID 23092657, compound → HCID 59300724, compound

HRID 2235396Notes

Reaction equation

HRID 2235396 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]([NH:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][C:22]=1[N+:23]([O-])=O)[N:19]([CH3:26])[C:18](=[O:27])[C:17]2([CH3:29])[CH3:28])=O>[Ni]>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]1[NH:13][C:14]2=[CH:15][C:16]3[C:17]([CH3:29])([CH3:28])[C:18](=[O:27])[N:19]([CH3:26])[C:20]=3[CH:21]=[C:22]2[N:23]=1

Participants

3

Reactant 1

HCID 23092657HCID 23092657, compound

Product 1

HCID 59300724HCID 59300724, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

2-[2-(2,4-Dichloro-phenyl)-ethyl]-5,7,7-trimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one is prepared from 3-(2,4-dichloro-phenyl)-N-(1,3,3-trimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-propionamide as described in Example 1b using Raney-nickel (71 mg) instead of Pd/C (497 mg).

Sources & evidence

ORD record
ord-6858d6e686e4488e99ab4659a0e1d3bf
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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