HCID 23092682, compound → HCID 178481495, compound

Participants

Reaction Steps

To a solution of 3-phenyl-N-(1,3,3-trimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-propionamide (125 mg; 248 μmol) in acetic acid (3 ml) is added iron powder (403 mg; 7 mmol). The mixture is heated and irradiated in a microwave apparatus (150° C.; 900 s). After re-cooling the mixture is filtered and evaporated. The residue is taken-up in water (40 ml) and saturated K2CO3 solution (10 ml) and extracted with CH2Cl2 (4×50 ml). The combined organic layer is dried over MgSO4 and concentrated in vacuo. The desired compound (55.0 mg) is obtained by preparative RP-HPLC eluting with a water/MeCN gradient.

Provenance & Evidence