HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Bicarbonate → 2,3-dihydro-7-methoxy-8-{3-[4-(2-pyrimidinyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Bicarbonate | HCID 516893 | — |
| Edukt | Fumarate | HCID 5460307 | — |
| Edukt | 2-Piperazinylpyrimidine dihydrochloride | HCID 11680272 | — |
| Edukt | 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927690 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Lösungsmittel | Chloroform | HCID 6212 | — |
| Produkt | 2,3-dihydro-7-methoxy-8-{3-[4-(2-pyrimidinyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927729 | 54% |
Reaktionsschritte
Method B (60 h at 50° C.; 4 equivalents of potassium hydrogencarbonate); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-pyrimidinyl)piperazine dihydrochloride; yield 54%; fusion point 184°-186° C. (from chloroform and ethanol). Fumarate: method E; yield 77%; fusion point 226°-228° C. (from acetone).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05428038 |
| Quelldatensatz | uspto-grants-1995_06 |
| ORD ID | ord-29ae1e67f57a4e9cbf6cce38fbf412f8 |
| Quellennotiz | uspto-grants-1995_06 |