Nitrogen → HCID 59300888, compound

Participants

Reaction Steps

To a solution of 5-butyl-2-(4-methoxy-phenyl)-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (150 mg) in dry THF (10 ml) under an inert atmosphere (N2) is added LiAlH4 (31.4 mg; 826 μmol). The reaction mixture is refluxed for 6 h and afterwards stirred at RT for another 15 h. Excess LiAlH4 is carefully hydrolyzed with NaOH solution (1 M; 30 ml). The aqueous layer is extracted with CH2Cl2 (3×30 ml). The combined organic layer is washed with brine, dried over MgSO4 and concentrated in vacuo to give the desired compound (140 mg).

Provenance & Evidence