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HRID2235410

反应详情

EQUATION

反应方程式

HRID 2235410 的结构方程式

REACTANTS

反应物

2
结构：CO.ClCCl
HCID21226129

未命名化合物

结构：CCCCCN1C(=O)C(C)(C)c2cc(NC(=O)CCc3cccc(N)c3)c([N+](=O)[O-])cc21
HCID23092670

未命名化合物

PRODUCTS

生成物

1
结构：CCCCCN1C(=O)C(C)(C)c2cc3[nH]c(CCc4cccc(NC(C)=O)c4)nc3cc21
HCID59300739

未命名化合物

PROCEDURE

实验过程

N-{3-[2-(7,7-Dimethyl-6-oxo-5-pentyl-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-ethyl]-phenyl}-acetamide is prepared from 3-(3-amino-phenyl)-N-(3,3-dimethyl-6-nitro-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-yl)-propionamide as described in Example 3b. Under the microwave conditions the acetylated product is formed. The desired N-{3-[2-(7,7-dimethyl-6-oxo-5-pentyl-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-ethyl]-phenyl}-acetamide (229 mg) is obtained by flash chromatography on silica gel eluting with CH2Cl2/MeOH (99:1).

WORKUP

后处理

  1. customUnder the microwave conditions the acetylated product is formed