HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2235413Generated: October 30, 2026
Methyl iodide → N-(3,3-Dimethyl-6-nitro-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-yl)-N-methyl-3-phenyl-propionamide
https://huagongshe.com/reaction/2235413
Participants
| Role | Name | HCID | Charge |
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| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(3,3-dimethyl-6-nitro-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide | HCID 23092643 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(3,3-Dimethyl-6-nitro-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-yl)-N-methyl-3-phenyl-propionamide | HCID 23092651 | — |
Reaction Steps
To a solution of N-(3,3-dimethyl-6-nitro-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide (142 mg) in dry N,N-dimethylformamide (6 ml) is added K2CO3 (163 mg; 1.18 mmol) and methyl iodide (45 μl; 0.72 mmol). The mixture is stirred at 75° C. for 2 days. After an aqueous work-up the compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07714010B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-99ce6d3f80434d1cb23d33bbc8185a3a |
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| Source note | uspto-grants-2010_05 |
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