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HRID2235417

反应详情

EQUATION

反应方程式

HRID 2235417 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(C(=O)Cl)cc1
HCID7477

Benzoyl chloride, 4-methoxy-

C8H7ClO2

结构：CC(C)CCN1C(=O)C(C)(C)c2cc(N)c([N+](=O)[O-])cc21
HCID23092666

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(C(=O)Nc2cc3c(cc2[N+](=O)[O-])N(CCC(C)C)C(=O)C3(C)C)cc1
HCID67425720

未命名化合物

收率 27.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.ClCCl
溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

N-[3,3-Dimethyl-1-(3-methyl-butyl)-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl]-4-methoxy-benzamide is prepared from A9 (419 mg) and 4-methoxy-benzoyl chloride (491 mg; 2.88 mmol) as described in Example 1a. N-[3,3-dimethyl-1-(3-methyl-butyl)-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl]-4-methoxy-benzamide (167 mg) is obtained by flash chromatography on silica gel eluting with CH2Cl2/MeOH (50:1)