反应详情

7,7-Diethyl-2-(4-methoxy-phenyl)-5-methyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one is prepared from N-(3,3-diethyl-1-methyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methoxy-benzamide (250 mg) by hydrogenation at 70° C. as described in Example 1b using Raney nickel (70 mg) as catalyst. The crude material is purified by flash chromatography on silica gel eluted with light petroleum/EtOAc (1:2) to give the compound (95 mg).

1. customThe crude material is purified by flash chromatography on silica gel
2. washeluted with light petroleum/EtOAc (1:2)