Hydrochloric Acid → HCID 178429298, compound

Participants

Reaction Steps

N-[5-(3-Fluoro-4-methoxy-benzyl)-7,7-dimethyl-6-oxo-3,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl]-benzamide (105 mg) is suspended in a BBr3 solution in CH2Cl2 (1 M; 700 μl) and stirred at RT for 18 h. After addition of hydrochloric acid (400 μl; 1 N) the mixture is stirred at RT for another 1 h and then evaporated to dryness. The crude material is purified by preparative RP-HPLC, eluted with MeCN/water to yield the desired compound (25 mg).

Provenance & Evidence