Hydrochloric Acid → HCID 178429299, compound

Participants

Reaction Steps

N-[5-(3,5-Difluoro-4-isopropoxy-benzyl)-7,7-dimethyl-6-oxo-3,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl]-benzamide (90 mg; 0.18 mmol) is suspended in a BBr3 solution in CH2Cl2 (1 M; 600 μl ) and stirred at RT for 18 h. After addition of hydrochloric acid (300 μl; 1 N) the mixture is stirred at RT for another 1 h and then evaporated to dryness. The crude material is purified by preparative RP-HPLC, eluted with MeCN/water to yield the desired compound (27.7 mg).

Provenance & Evidence