反应详情

To a solution of C1 (3.1 g) and dry pyridine (3.5 ml; 42 mmol) in dry CH2Cl2 (75 ml) is added 4-methoxy-benzoyl chloride (2.63 g; 15.4 mmol) over a period of 2 min. After addition the mixture is stirred at RT for 20 h. CHCl3 (200 ml) is added and the organic layer is washed with sodium hydroxide solution (0.5 N) and water, dried over MgSO4 and concentrated in vacuo. The crude material is triturated with boiling EtOH and the precipitate is collected by filtration (3.73 g).

1. additionAfter addition the mixture
2. washthe organic layer is washed with sodium hydroxide solution (0.5 N) and water
3. dry with materialdried over MgSO4
4. concentrationconcentrated in vacuo
5. customThe crude material is triturated with boiling EtOH
6. filtrationthe precipitate is collected by filtration (3.73 g)