反应详情

温度

150 °C

A solution of N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methoxy-benzamide (200 mg) and propyl isocyanate (59 μl) in dry toluene (2 ml) is stirred in a microwave apparatus at 150° C. for 900 s. The resulting solid is collected by filtration, dissolved in acetic acid (3 ml) and iron (200 mg; powder) is added and the mixture is again stirred in a microwave apparatus at 150° C. for 900 s to achieve reduction of the nitro function and ring closure. The mixture is filtered and concentrated in vacuo. The desired compound (65 mg) is obtained by preparative RP-HPLC.

1. filtrationThe resulting solid is collected by filtration
2. dissolutiondissolved in acetic acid (3 ml)
3. additioniron (200 mg; powder) is added
4. filtrationThe mixture is filtered
5. concentrationconcentrated in vacuo