反应详情

温度

150 °C

A solution of N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-4-methoxy-benzamide (100 mg) and phenyl isocyanate (35 mg; 0.3 mmol) in dry toluene (2 ml) is stirred in a microwave apparatus at 150° C. for 900 s. The mixture is filtered and concentrated in vacuo. The residue is dissolved in acetic acid (2 ml), iron (115 mg; powder) is added and the mixture is again stirred in a microwave apparatus at 150° C. for 900 s to achieve reduction of the nitro function and ring closure. The mixture is filtered and concentrated in vacuo. The desired compound (26 mg) is obtained by preparative RP-HPLC.

1. filtrationThe mixture is filtered
2. concentrationconcentrated in vacuo
3. dissolutionThe residue is dissolved in acetic acid (2 ml)
4. additioniron (115 mg; powder) is added
5. filtrationThe mixture is filtered
6. concentrationconcentrated in vacuo