Nitric Acid → HCID 86601810, compound

Participants

Reaction Steps

To a solution of 2,2,2-trifluoro-N-(1′-methyl-2′-oxo-spiro[cyclopropane-1,3′-indole]-5′-yl)-acetamide (2 g) in acetic acid (20 ml) at 15° C. is added nitric acid (fuming, 0.8 ml) over a period of 3 min. The mixture is stirred at this temperature for 1 h and then diluted with water. The aqueous layer is extracted with EtOAc. The combined organic layer is washed with water, saturated K2CO3 solution and brine, dried over MgSO4 and evaporated. The compound (2.25 g) is obtained as a brown semi-solid.

Provenance & Evidence