Thiourea → HCID 178437128, compound

HRID 223546Notes

Reaction equation

HRID 223546 reaction equation
[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][Cl:10])[C:5]([CH:11]=[CH2:12])=[CH:4][N:3]=1.[NH2:13][C:14]([NH2:16])=[S:15]>C(O)C>[ClH:10].[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH2:9][NH:16][C:14](=[NH:13])[SH:15])[C:5]([CH:11]=[CH2:12])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 202639602-Methyl-3-hydroxy-4-chloromethyl-5-vinylpyridine

Product 1

HCID 178437128HCID 178437128, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 21.0 g. of 2-methyl-3-hydroxy-4-chloromethyl-5-vinylpyridine, 6.74 g. of thiourea, and 200 ml. of ethanol was refluxed 3 hours. The cooled mixture was filtered and the solids were washed with ether to give 2-methyl-3-hydroxy-4-isothioureidomethyl-5-vinylpyridine hydrochloride.

Workup

  1. additionA mixture of 21.0 g
  2. filtrationThe cooled mixture was filtered
  3. washthe solids were washed with ether

Sources & evidence

ORD record
ord-00ec16cb5ebf4b619510d9fecf716e33
Source dataset
uspto-grants-1982_10
Patent number
US04355034

Reaction notes

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