Water → HCID 67426946, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of D1 (210 mg) and DIPEA (4 ml; 23 mmol) in 1,4-dioxane (5.5 ml) is added benzoyl chloride (158 μl) at RT. The mixture is stirred for 20 h at RT and 2 h at 80° C. After completion of the reaction water is added and the aqueous layer is extracted with EtOAc. The combined organic layer is washed with saturated NaHCO3 solution and brine, dried over MgSO4 and concentrated in vacuo. Purification by flash chromatography on silica gel eluting with CH2Cl2/MeOH (98:2) afforded the desired compound (135 mg).

Provenance & Evidence