HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → N-(7,7-Dimethyl-6-oxo-5-pentyl-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 2-Amino-7,7-dimethyl-5-pentyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one | HCID 59300824 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(7,7-Dimethyl-6-oxo-5-pentyl-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-benzamide | HCID 59300899 | — |
Reaction Steps
A solution of D5 (100 mg) and benzoyl chloride (298 mg; 2.12 mmol) in pyridine (12 ml) is stirred at RT for 20 h and then at 80° C. for 2 h. After an aqueous work-up the desired compound is obtained by flash chromatography on silica gel eluted with EtOAc/MeOH (99.5:0.5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714010B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-f08d7de1a72d4f2d947e497c268927c9 |
| Source note | uspto-grants-2010_05 |