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HRID2235469

反应详情

EQUATION

反应方程式

HRID 2235469 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)c1ccccc1
HCID7412

Benzoyl chloride

C7H5ClO

结构：CCCCCN1C(=O)C(C)(C)c2cc3c(cc21)nc(NC)n3S(=O)(=O)c1ccc(C)cc1
HCID67426693

未命名化合物

PRODUCTS

生成物

1
结构：CCCCCN1C(=O)C(C)(C)c2cc3[nH]c(N(C)C(=O)c4ccccc4)nc3cc21
HCID59301013

未命名化合物

收率 35.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

CONDITIONS

反应条件

温度
130 °C

PROCEDURE

实验过程

To a solution of 7,7-dimethyl-2-methylamino-5-pentyl-1-(toluene-4-sulfonyl)-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (120 mg) in pyridine (5 ml) is added drop-wise benzoyl chloride (0.1 ml; 0.79 mmol) at 0° C. After addition the mixture is heated at 130° C. for 5 h. An aqueous work-up and purification by flash chromatography on silica gel eluting with CH2Cl2/MeOH (40:1) yield the desired compound (38 mg).

WORKUP

后处理

  1. additionAfter addition the mixture
  2. customAn aqueous work-up and purification by flash chromatography on silica gel eluting with CH2Cl2/MeOH (40:1)