HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nicotinic Acid → HCID 178452695, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nicotinic Acid | HCID 938 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178452696 | HCID 178452696 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178452695 | HCID 178452695 | — |
Reaction Steps
A solution of nicotinic acid (11.8 mg; 0.09 mmol), TBTU (28.1 mg; 0.09 mmol) and DIPEA (33 μl) in N,N-dimethylformamide (600 μl) is stirred at RT for 5 min. Afterwards D18 (26.5 mg) is added and the mixture is stirred at RT for 18 h. After evaporation of the solvent the crude material is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07714010B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-600d2d193dac4653a95569d61b2e8810 |
| Source note | uspto-grants-2010_05 |