Potassium Carbonate → HCID 178429291, compound

Participants

Reaction Steps

(2-{7,7-Dimethyl-6-oxo-2-[(pyridine-3-carbonyl)-amino]-6,7-dihydro-3H-imidazo[4,5-f]indol-5-ylmethyl}-phenyl)-carbamic acid tert-butyl ester (33.2 mg) is dissolved in CH2Cl2 (4 ml) and TFA (1.5 ml). The mixture is stirred at RT for 0.5 h. Saturated K2CO3 solution is added and the aqueous layer is extracted with CH2Cl2. The organic layer is dried over MgSO4, evaporated to dryness and the residue is purified by RP-HPLC, eluted with MeCN/water to give the desired product (4,5 mg).

Provenance & Evidence