Hydrochloric Acid → HCID 178425297, compound

Participants

Reaction Steps

N-[5-(4-Fluoro-2-methoxy-benzyl)-7,7-dimethyl-6-oxo-3,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl]-3-methyl-benzamide (5 mg) is suspended in a BBr3 solution in CH2Cl2 (1 M; 33 μl) and stirred at RT for 10 h. After addition of hydrochloric acid (200 μl; 1 N) the mixture is stirred at RT for another 1 h and then evaporated to dryness. The crude material is purified by preparative RP-HPLC eluted with MeCN/water to yield the desired compound (3.2 mg).

Provenance & Evidence