Thiophenol → HCID 59300778, compound

Participants

Reaction Steps

To a solution of thiophenol (70 μl) in CH2Cl2 (4 ml) is added NaH (43 mg; 1.08 mmol) and the resulting suspension is stirred for 5 min at RT. Then freshly prepared 2-chloromethyl-7,7-dimethyl-5-pentyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (265 mg) dissolved in CH2Cl2 (5 ml) is added and the mixture is stirred at 40° C. for 20 h. After cooling to 0° C. 3-chloro-benzenecarboperoxoic acid (186 mg; 0.83 mmol) is added and stirring is continued for another 3 h. After completion of the reaction the mixture is concentrated in vacuo and purified by NP-HPLC eluting with CH2Cl2/MeOH to give the desired compound (5.8 mg).

Provenance & Evidence