2,4,6-Trimethylphenyl isothiocyanate → 1-[4-(Dipropylamino)pyridin-2-yl]-3-mesitylthiourea

Participants

Reaction Steps

To 0.106 g (0.0.55 mmol) of N4,N4-dipropylpyridine-2,4-diamine in 10 mL of methanol was added 0.117 g (0.66 mmol) of mesitylisothiocyanate. The mixture was heated at reflux for 24 h, diluted with water and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered, concentrated in vacuo and the resulting crude solid was purified by flash chromatography eluting with a 85% hexanes/ethyl acetate mixture to give 0.044 g (22%) of the title compound as a white solid.

Provenance & Evidence