反应详情

To 0.040 g (0.11 mmol) of 1-[4-(Dipropylamino)pyridin-2-yl]-3-mesitylthiourea in 2 mL of glacial acetic acid was added 6.1 μL (0.12 mmol) of bromine. After 30 min at room temperature, an additional 2 μL of bromine was added. The reaction mixture was concentrated after 2 h and washed with ethyl acetate/hexanes. The organics were concentrated and the resulting oil was purified by flash chromatography eluting with a 4% methanol/dichloromethane mixture to give 0.020 g (50%) of the title compound as a light yellow powder.

1. concentrationThe reaction mixture was concentrated after 2 h
2. washwashed with ethyl acetate/hexanes
3. concentrationThe organics were concentrated
4. customthe resulting oil was purified by flash chromatography
5. washeluting with a 4% methanol/dichloromethane mixture