Ammonia → (3-Nitrophenyl)thiourea

HRID 2235497Notes

Reaction equation

HRID 2235497 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([N:10]=[C:11]=[S:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[NH3:13]>CO>[N+:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11]([NH2:13])=[S:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19050Benzene, 1-isothiocyanato-3-nitro-

Product 1

HCID 2754758(3-Nitrophenyl)thioureaYield 100.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To 7.20 g (40 mmol) of 3-nitrophenylisothiocyanate in 25 mL of methanol was added 28.5 mL (200 mmol) of 7 N ammonia in methanol. After 30 min., the slurry was concentrated to give 7.9 g (100%) of the title compound as a yellow-orange powder that did not require further purification.

Workup

  1. concentrationthe slurry was concentrated

Sources & evidence

ORD record
ord-4b01215cefe74988952da9fd058966eb
Source dataset
uspto-grants-2010_05
Patent number
US07714009B2

Reaction notes

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