2,4,6-Trimethylaniline → HCID 86049082, compound

HRID 2235511Notes

Reaction equation

HRID 2235511 reaction equation
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6]([N+:11]([O-:13])=[O:12])[CH:5]=1)=[C:2]=[S:3].[CH3:14][C:15]1[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]([CH3:23])[C:16]=1[NH2:17]>CO>[C:15]1([CH3:14])[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]([CH3:23])[C:16]=1[NH:17][C:2]([NH:1][C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[C:6]([N+:11]([O-:13])=[O:12])[CH:5]=1)=[S:3]

Participants

4

Reactant 2

HCID 69132,4,6-TrimethylanilineHCID 50998334HCID 50998334, compound

Product 1

HCID 86049082HCID 86049082, compoundYield 71.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4-isothiocyanato-1-methyl-2-nitrobenzene (500 mg, 2.58 mmol) and 2,4,6-trimethylaniline (0.329 ml, 2.34 mmol) in methanol (10 ml) was refluxed for 4 h. The solvent was evaporated under vacuum. The residue was triturated with ether. The resulting solid was collected by filtration to afford 550 mg of the title compound.

Workup

  1. temperaturewas refluxed for 4 h
  2. customThe solvent was evaporated under vacuum
  3. customThe residue was triturated with ether
  4. filtrationThe resulting solid was collected by filtration

Sources & evidence

ORD record
ord-db5d7a9b843d4cf4a91ccd042aca35f5
Source dataset
uspto-grants-2010_05
Patent number
US07714009B2

Reaction notes

Loading…