反应详情

To 0.45 g (1.9 mmol) of 3-(tert-butyldimethylsilyloxymethyl)aniline in 3 mL of methanol was added 0.67 g (3.8 mmol) of mesitylisothiocyanate. The mixture was heated at reflux for 18 h. The mixture was concentrated and purified by flash chromatography eluting with a 16% ethyl acetate/hexanes mixture to give 0.56 (71%) of the title compound as a sticky white solid.

1. temperatureThe mixture was heated
2. temperatureat reflux for 18 h
3. concentrationThe mixture was concentrated
4. custompurified by flash chromatography
5. washeluting with a 16% ethyl acetate/hexanes mixture