反应详情

To a mixture containing 0.10 g (0.65 mmol) of 2-amino-6-nitrophenol and 0.14 g (1.3 mmol) of sodium carbonate in ethanol was added 0.14 g (0.78 mmol) of 2-isothiocyanato-1,3,5-trimethylbenzene. The reaction was heated at reflux overnight. The reaction was cooled to room temperature, filtered and concentrated under reduced pressure. Purification of the residue via Biotage chromatography eluting with 20% ethyl acetate/dichloromethane gave 0.17 g (80%) of product.

1. temperatureThe reaction was heated
2. temperatureat reflux overnight
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customPurification of the residue via Biotage chromatography
6. washeluting with 20% ethyl acetate/dichloromethane