反应详情

To a mixture containing 0.25 g (1.82 mmol) of N2-methylbenzene-1,2,3-triamine and 0.40 g (3.7 mmol) of sodium carbonate in ethanol was added 0.32 g (1.86 mmol) of 2-isothiocyanato-1,3,5-trimethylbenzene. The reaction was heated at reflux and the solvent was removed under reduced pressure. Purification of the residue via Biotage chromatography eluting with 20% ethyl acetate/dichloromethane gave 0.34 g (60%) of product.

1. temperatureThe reaction was heated
2. temperatureat reflux
3. customthe solvent was removed under reduced pressure
4. customPurification of the residue via Biotage chromatography
5. washeluting with 20% ethyl acetate/dichloromethane