Phosphorus oxychloride → 2-Chloro-5-fluoro-1,3-dinitrobenzene

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.65 g (2.2 mmol) of 4-fluoro-2,6-dinitrophenol in 30 mL dimethylformamide was added 1.4 mL (15 mmol) of phosphorous oxychloride. The mixture was heated to 70° C. overnight, cooled to room temperature and quenched with ice. The mixture was diluted with water and the precipitate was collected giving 1.35 g (82%) of the title compound as a cream colored solid.

Provenance & Evidence