Phosphorus oxychloride → HCID 68581147, compound

Participants

Reaction Steps

A mixture of 4-bromo-7-dipropylamino-1-methyl-1,3-dihydro-2H-benzimidazol-2-one (210 mg, 0.644 mmol) and phosphorus oxychloride (3.0, 32 mol) was refluxed for 18 h with stirring and concentrated to dryness under vacuum. The residue was diluted with water. The aqueous solution was extracted with dichloromethane. The extract was washed with water, dried over magnesium sulfate and concentrated under vacuum to afford 220 mg (99%) of the title compound. The residue was used for the next reaction without further purification.

Provenance & Evidence