2,4,6-Trimethylaniline → HCID 11154972, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-bromo-2-chloro-1-methyl-N,N-dipropyl-1H-benzimidazol-7-amine (220 mg, 0.638 mmol) and mesityl amine (1.79 ml, 12.8 mmol) was heated at 120° C. for 60 h. The mixture was dissolved in ethyl acetate and washed with saturated sodium bicarbonate in water, dried over magnesium sulfate and concentrated under vacuum. The residue was purified by column chromatography eluting 5% n-hexane/ethyl acetate to afford the title compound.

Provenance & Evidence