Trifluoroacetic acid → 7-[(4-Chlorophenyl)(isopropyl)amino]-1-methyl-1,3-dihydro-2H-benzimidazol-2-one

Participants

Reaction Conditions

Reaction Steps

To a mixture of 7-[(4-chlorophenyl)(isopropyl)amino]-3-(4-methoxybenzyl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one (80 mg, 0.18 mmol) and trifluoroacetic acid (3 ml) was stirred at 65° C. for 19 h. The mixture was concentrated in vacuo, diluted with saturated aqueous sodium bicarbonate (20 ml) and extracted with ethyl acetate (30 ml). The extract was washed with water, dried over magnesium sulfate and evaporated. The residue was flash chromatographed eluting with a 33% ethyl acetate/hexanes to give 26.8 mg (34%) of the title compound as an oil.

Provenance & Evidence