反应详情

To a slurry of 39 g of aluminum chloride and 120 ml of 1,3-difluorobenzene was added dropwise, with stirring, 30 g of N-formylisonipecotic acid chloride. The reaction mixture was stirred under reflux for two hrs and poured into 1 l of ice-water. The mixture was extracted with 4 350-ml portions of chloroform. The combined organic extracts were washed with 2 300-ml portions of water, dried, filtered and evaporated. Trituration with petroleum ether and washing with ether at 0°, yielded 14 g (32.3%) of product, mp, 75°.

1. stirringThe reaction mixture was stirred
2. temperatureunder reflux for two hrs
3. extractionThe mixture was extracted with 4 350-ml portions of chloroform
4. washThe combined organic extracts were washed with 2 300-ml portions of water
5. customdried
6. filtrationfiltered
7. customevaporated
8. washTrituration with petroleum ether and washing with ether at 0°