反应详情

To a solution of 1.73 g (11.6 mmol) of 3-methyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one in 6.3 mL of concentrated sulfuric acid, cooled in an 0° C. ice bath, was slowly added a solution of 1.50 mL (36.0 mmol) of fuming nitric acid in 1.5 mL of concentrated sulfuric acid. The reaction was removed from the ice bath and stirred for 0.5 h at room temperature and then heated at 100° C. for 2 h. The reaction was quenched over 300 mL of ice and solid ammonium carbonate was added to adjust the pH to 9. The resulting slurry was filtered and the collected solids washed with water and dried under high vacuum to give 1.94 g (86%) of the title compound.

1. customThe reaction was removed from the ice bath
2. temperatureheated at 100° C. for 2 h
3. customThe reaction was quenched over 300 mL of ice and solid ammonium carbonate
4. additionwas added
5. filtrationThe resulting slurry was filtered
6. washthe collected solids washed with water
7. customdried under high vacuum