Hydrochloric Acid → HCID 59252188, compound

Participants

Reaction Conditions

Reaction Steps

Diethylamine (11 μL, 0.11 mmol) and NaCNBH3 (10 mg, 0.16 mmol) were added to a solution of compound 54.4 (54 mg, 0.089 mmol) in DCE (2 mL). The reaction mixture was stirred at 60° C. for 18 hours and then 1N HCl aqueous solution was added. The solution was stirred for 5 minutes and then partitioned between saturated aqueous NaHCO3 solution and DCM. The organic layer was collected, dried over MgSO4 and concentrated in vacuo. The crude product was used without further purification. MS ESI (pos.) m/e: 665 (M+H).

Provenance & Evidence