HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 6-methoxy-7-(oxiranylmethoxy)-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Scopoletin | HCID 5280460 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-methoxy-7-(oxiranylmethoxy)-2H-1-benzopyran-2-one | HCID 19927717 | — |
Reaction Steps
25.0 g (130 mmol) of scopoletine, 15.3 ml (196 mmol) epichlorohydrin, 36.0 g (260 mmol) potassium carbonate and 2.5 g of potassium iodide are agitated in 500 ml DMF under nitrogen for 3 h at 80° C. After vacuum evaporation and repeated extraction with hot ethanol re-evaporation was performed. 21.2 g (66%); fusion point 143°-145° C. (from ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-0fed15fd2091475685652c7edc9bf58e |
| Source note | uspto-grants-1995_06 |