Hydrazine → 2-(4-Fluorophenyl)-4-hydroxy-2-methoxybutyric acid hydrazide

HRID 2235748Notes

Reaction equation

HRID 2235748 reaction equation
[NH2:1][NH2:2].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([O:16][CH3:17])[CH2:14][CH2:13][O:12][C:11]2=[O:15])=[CH:6][CH:5]=1>C(O)C>[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([O:16][CH3:17])([CH2:14][CH2:13][OH:12])[C:11]([NH:1][NH2:2])=[O:15])=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 670671553-(4-Fluorophenyl)-3-methoxydihydrofuran-2-one

Product 1

HCID 670673452-(4-Fluorophenyl)-4-hydroxy-2-methoxybutyric acid hydrazideYield 96.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of hydrazine (29 mg) in ethanol (0.5 mL) was added to a solution of 3-(4-fluorophenyl)-3-methoxydihydrofuran-2-one (37 mg) in ethanol (1.2 mL), and the reaction solution was stirred at room temperature for 2.5 hours. The reaction solution was concentrated under reduced pressure to obtain 41 mg of the title compound. The property values of the compound are as follows.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d266701497504887bd0ddaf44430526e
Source dataset
uspto-grants-2010_05
Patent number
US07713993B2

Reaction notes

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