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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2235751Generated: October 29, 2026

Ethyl Acetate → HCID 178489922, compound

https://huagongshe.com/reaction/2235751

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl AcetateHCID 8857—
ReactantPotassium CarbonateHCID 11430—
ReactantHCID 178489924HCID 178489924—
SolventMethanolHCID 887—
SolventSodium chloride; waterHCID 57417360—
ProductHCID 178489922HCID 17848992288.3%

Reaction Steps

Potassium carbonate (210 mg) was added to a solution of 4-{5-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-4H-[1,2,4]triazol-3-yl}-4-(3,4,5-trifluorophenyl)butyl acetate (400 mg) in methanol (3 mL), and the reaction solution was stirred at room temperature for three hours. Ethyl acetate and brine were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 325 mg of the title compound. The property values of the compound are as follows.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07713993B2
Source datasetuspto-grants-2010_05
ORD IDord-c6e9a97592724f37ab53da003232b981
Source noteuspto-grants-2010_05