Acrylic Acid → HCID 66918055, compound

HRID 2235810Notes

Reaction equation

HRID 2235810 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[F:24])[O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[C:8](/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19])=[CH:9][N:10]2[CH3:15].[C:25](O)(=O)[CH:26]=C>>[CH2:25]([O:19][C:18](=[O:20])/[CH:17]=[CH:16]/[C:8]1[C:7]2[C:11](=[CH:12][CH:13]=[CH:14][C:6]=2[O:5][C:4]2[CH:21]=[CH:22][C:23]([F:24])=[C:2]([Cl:1])[CH:3]=2)[N:10]([CH3:15])[CH:9]=1)[CH3:26]

Participants

3

Reactant 2

HCID 6581Acrylic AcidHCID 66918119HCID 66918119, compound

Product 1

HCID 66918055HCID 66918055, compound

Procedure

Synthesis of (E)-3-[4-(3-Chloro-4-fluoro-phenoxy)-1-methyl-1H-indol-3-yl]-acrylic acid, A38. Following the general procedure P-8, K-59G was hydrolyzed to acrylic acid A38. 1H NMR (DMSO-d6) 3.85 (s, 3H), 6.24 (d, J=16 Hz, 1H), 6.66 (d, J=8 Hz, 1H), 7.00 (m, 1H), 7.20 (dd, J=8 and 8 Hz, 1H), 7.25 (m, 1H), 7.35 (d, J=8 Hz, 1H), 7.43 (dd, J=9 and 9 Hz, 1H), 7.88 (d, J=16 Hz, 1H), 8.07 (s, 1H), 11.8 (s, 1H).

Sources & evidence

ORD record
ord-70ca2b389ffc4043afe10acaf93535c8
Source dataset
uspto-grants-2010_05
Patent number
US07714017B2

Reaction notes

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