1-Bromo-2-nitrobenzene → 7-Bromo-3-methyl-1H-indole

HRID 2235814Notes

Reaction equation

HRID 2235814 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-])=O.[CH2:11]([Mg]Br)[CH:12]=[CH2:13]>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:8][CH:11]=[C:12]2[CH3:13]

Participants

3

Reactant 2

HCID 113411-Bromo-2-nitrobenzeneHCID 178455850HCID 178455850, compound

Product 1

HCID 130306067-Bromo-3-methyl-1H-indole

Procedure

2-Bromo nitrobenzene was reacted with allyl magnesium bromide according to the literature procedure (Dobbs A. J. Org Chem. 2001, 66, 638-641), to provide 7-bromo-3-methyl-1H-indole (K-82).

Sources & evidence

ORD record
ord-dd741e0a6a134146b8cb43b2072840a4
Source dataset
uspto-grants-2010_05
Patent number
US07714017B2

Reaction notes

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