HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-1-propanol → 2,3-dihydro-8-(3-hydroxypropoxy)-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-1-propanol | HCID 12313 | — |
| Reactant | Potassium Bicarbonate | HCID 516893 | — |
| Reactant | 2,3-dihydro-8-hydroxy-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927677 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2,3-dihydro-8-(3-hydroxypropoxy)-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927648 | 58% |
Reaction Steps
Method J (but using potassium hydrogencarbonate); Starting materials: 2,3-dihydro-8-hydroxy-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 109) and 3-chloro-1-propanol; yield 58%; fusion point 213°-215° C. (from isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-ce7b2c4cccf04c1c9483a6157345c6e0 |
| Source note | uspto-grants-1995_06 |