Ethyl Bromide → HCID 15581179, compound

Participants

Reaction Steps

To a mixture of 3.3 g (0.013 mol) of 3-carbomethoxy-4-hydroxy-7-methyl-pyrido[3',2':4,5]thieno[3,2-C]pyridazine, 3.8 g potassium bicarbonate, in 90 ml of anhydrous DMF was slowly added 9 ml of ethyl bromide and stirring was continued at 60°-70° C. for 3 hours. The solvent was then removed, the residue was diluted with water and filtered to give 3.4 g of crude product. Crystallization from EtoAc-hexane gave 1.8 g (46%) of pure 3-carbethoxy-4-ethoxy-7-methyl pyrido[3',2':4,5]thieno[3,2-C]pyridazine; m.p. 158°-160° C.

Provenance & Evidence